SCS Bulletin Board Post

SUBJECT: Diversity-Oriented Synthesis and Natural Product Chemistry



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Edel O'Regan Through diversity-oriented synthesis, chemists are achieving more structural complexity than in the early days of combinatorial chemistry, tackling compounds with multiple stereocenters and complex, natural product-like libraries. Preparation of structurally complex and diverse compounds results in a broader population of chemical space and facilitates effective probing of biological space. Structural complexity is very significant because many of the small molecules known to disrupt protein-protein interactions are complex natural products or natural product-like compounds. The potential for therapeutic development depends however not only upon structural complexity but also upon synthetic accessibility and scalability. Achieving this difficult balance demands innovative chemistry such as that described at this symposium. Attend this event to hear the latest developments in diversity-oriented synthesis and its impact on drug development.

link to event webpage



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